xbridge beh c18 obd prep column (Waters Corporation)

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Waters Corporation xbridge beh c18 obd prep column
Xbridge Beh C18 Obd Prep Column, supplied by Waters Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/xbridge+beh+c18+obd+prep+column/us12043623-556-19-18
Average 86 stars, based on 1 article reviews

xbridge beh c18 obd prep column - by Bioz Stars, 2026-10

86/100 stars

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Purification:

Article Title: Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Article Snippet: Inhibition of KEAP1-NRF2 protein-protein interaction is considered a promising strategy to selectively and effectively activate NRF2, a transcription factor which is involved in several pathologies such as Huntington’s disease (HD).. A library of linear peptides based on the NRF2-binding motifs was generated on the nonapeptide lead Ac-LDEETGEFL-NH2 spanning residues 76–84 of the Neh2 domain of NRF2 with the aim to replace E78, E79 and E82 with non-acidic amino acids.. A deeper understanding of the features and accessibility of the T80 subpocket was also targeted by structure-based design.

Article Title: A Fungal P450 Enzyme from Fusarium graminearum with Unique 12β-Steroid Hydroxylation Activity.
Article Snippet: In this study, a new cytochrome P450 enzyme, namely, CYP68J5_Fusarium graminearum (CYP68J5_fg), was identified from Fusarium graminearum via a combination of transcriptome sequencing and heterologous expression in Saccharomyces cerevisiae.. The biotransformation of progesterone by whole-cells of S. cerevisiae expressing CYP68J5_fg revealed that the CYP68J5_fg possessed steroidal 12band 15a-hydroxylase activities.. To the best of our knowledge, this is the first time that a fungal P450 enzyme with 12bhydroxylase activity has been identified.

Article Title: SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.
Article Snippet: Zika virus (ZIKV) is a member of the Flaviviridae family that can cause neurological disorders and congenital malformations.. The NS2B-NS3 viral serine protease is an attractive target for the development of new antiviral agents against ZIKV.. We report here a SAR study on a series of substrate-like linear tripeptides that inhibit in a non-covalent manner the NS2B-NS3 protease.

High Performance Liquid Chromatography:

Article Title: Purinones as ubiquitin-specific protease 1 inhibitors
Article Snippet: .. Conditions: Mobile phase A: water with 0.1% ammonium hydroxide; Mobile phase B: acetonitrile with 0.1% ammonium hydroxide Column: Waters XBridge BEH C18 OBD Prep Column, 130 Å, 5 μm, 19 mm×50 mm Column temperature: Ambient LC gradient: Hold 15% B for 0.9 min, then 15% to 25% in 0.01 min; then 25% to 65% in 3.84 min; then 65 to 100% to 100% in 0.01 min; hold at 100% for 0.74 min, then 100% to 0% in 0.01 min; hold at 0% for 0.49 min. LC Flow rate: 23 mL/min binary pump, 2 mL/min acetonitrile at column dilution UV wavelength: 220 nm and 254 nm Ionization Mode: ESI positive/negative Preparative HPLC Generic Method 5 (ESI, 6 Min Method): Instruments: HPLC: Waters 2545 Binary Gradient Module. .. Conditions: Mobile phase A: water with 0.1% ammonium hydroxide; Mobile phase B: acetonitrile with 0.1% ammonium hydroxide Column: Waters XBridge BEH C18 OBD Prep Column, 130 Å, 5 μm, 19 mm×50 mm Column temperature: Ambient LC gradient: Hold 0% B for 0.9 min, then 0% to 5% in 0.01 min; then 5% to 35% in 3.84 min; then 35% to 100% in 0.01 min; hold at 100% for 0.74 min, then 100% to 0% in 0.01 min; hold at 0% for 0.49 min. LC Flow rate: 23 mL/min binary pump, 2 mL/min acetonitrile at column dilution UV wavelength: 220 nm and 254 nm Ionization Mode: ESI positive/negative Preparative HPLC Polar Method 3 (ESI, 6 Min Method): Instruments: HPLC: Waters 2545 Binary Gradient Module.

Article Title: Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
Article Snippet: Data was acquired using Waters MassLynx 4.1 software and purity characterized by UV wavelength 220 nm, evaporative light scattering detection (ELSD) and electrospray positive ion (ESI). (Column: Acquity UPLC BEH C18 1.7 μm 2.1×50 mm; Flow rate 0.6 mL/min; Solvent A (95/5/0.1%: 10 mM Ammonium Formate/Acetonitrile/Formic Acid), Solvent B (95/5/0.09%: Acetonitrile/Water/Formic Acid); gradient: 5-100% B from 0 to 2 mins, hold 100% B to 2.2 mins and 5% B at 2.21 mins. .. Preparatory HPLC purifications were conducted on a Waters SunFire C18 OBD Prep Column, 100 Å, 5 μm, 19 mm×50 mm, Waters XBridge BEH C18 OBD Prep Column, 130 Å, 5 μm, 19 mm×50 mm with UV detection (Waters 2489 UV/998 PDA), Waters SunFire C18 OBD Prep Column, 100 Å, 5 μm, 19 mm×150 mm, Waters XBridge BEH Shield RP18 OBD Prep Column, 130 Å, 5 μm, 19 mm×150 mm, or Waters XSelect CSH C18 OBD Prep Column, 130 Å, 5 μm, 19 mm×150 mm at 254 nm or 220 nm using a standard solvent gradient program (or as designated below). .. Mass spectra were collected using a Waters ZQ Single Quad Mass Spectrometer (ion trap electrospray ionization (ESI)).

Article Title: Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library.
Article Snippet: The recombination of natural product (NP) fragments in unprecedented ways has emerged as an important strategy for bioactive compound discovery.. In this context, we propose that privileged primary fragments predicted to be enriched in activity against a specific target class can be coupled to diverse secondary fragments to engineer selectivity among closely related targets.. Here, we report the synthesis of an alkaloid-inspired compound library enriched in spirocyclic ring fusions, comprising 58 compounds from 12 tropaneor quinuclidine-containing scaffolds, all of which can be considered pseudo-NPs.

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Article Title: Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels.
Article Snippet: LC-MS analysis LC-MS analysis of crude reaction mixtures and pure products were performed on a Waters Acquity H-class UPLC equipped with Waters Acquity eLambda PhotoDiodeArray detector (l = 210-800 nm), Waters UPLC BEH C4 column (300 Å, 1.7 mm, 2.1 x 50 mm) and LCT ESI Mass Spectrometer (Column Temp = 40 C).

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